GSK3?-Mediated Expression of CUG-Translated WT1 Is Critical for Tumor Progression

Abstract The Wilms' tumor 1 (WT1) gene is well known as a chameleon gene. It plays role suppressor in but also acts an oncogene other cancers. Previously, our group reported that canonical AUG starting site for the WT1 protein (augWT1) suppressor, whereas CUG (cugWT1) functions oncogene. In this study, we report oncogenic of cugWT1 AOM/DSS-induced colon cancer mouse model and urethane-induced lung mice lacking cugWT1. Development chemically-induced tumors was significantly depressed cugWT1-deficient mice. Moreover, glycogen synthase kinase 3? promoted phosphorylation at S64, resulting ubiquitination degradation associated with F-box?/? WD repeat-containing 8. Overall, findings suggest inhibition expression provides potential candidate target therapy. Significance: These demonstrate CUG-translated vivo, GSK3?-mediated induces its concert FBXW8.